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Molecular pathology and neuroimaging teaching files
Molecular pathology and neuroimaging teaching files
Jon Wilson 1, Eduardo González-Toledo 2
1 Arkana Laboratories, Little Rock, Arkansas, Estados Unidos de América; 2 Dirección, Unidad Académica en Diagnóstico por Imágenes, Hospital Sirio-Libanés, Buenos Aires, Argentina
*Correspondence: Eduardo González-Toledo. Email: ecgtoledo@gmail.com
Abstract
We present the case of a 20-year-old female patient with neurological symptoms whose magnetic resonance imaging (MRI) revealed a left frontoinsular mass. Multiparametric MRI — including diffusion-weighted imaging, diffusion tensor imaging), resting-state functional MRI, and ALPS (along the perivascular space) index — suggested an IDH (isocitrate dehidrogenase) mutant, 1p/19q non-codeleted glioma. Histopathological and molecular analyses confirmed the imaging-based hypothesis. This case highlights the power of advanced MRI techniques in the preoperative molecular characterization of gliomas.
Keywords: Molecular pathology. Development indicators. Glymphatic system. Diffusion.
