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Hepatocellular carcinoma in non-cirrhotic liver: our experience in computed tomography and magnetic resonance imaging
Hepatocellular carcinoma in non-cirrhotic liver: our experience in computed tomography and magnetic resonance imaging
Silvina V. Quintana 1, Maren Donato 1, Nilda E. Vergara-Mercado 1, Esteban A. Sela 1, Gerardo C. Ramón 1, Alejandro Schroeder 1
1 Departamento de Tomografía Computada y Resonancia Magnética, Leben Salud, Neuquén, Argentina
*Correspondence: Silvina V. Quintana. Email: squintana@lebensalud.com
Abstract
Introduction: Hepatocellular carcinoma (HCC) develops in liver with chronic liver disease, being the main risk factor. However, 10-12% of HCC develop in non-cirrhotic liver.
Objective: To determine computed tomography (CT) and magnetic resonance imaging (MRI) features in a case series of path-proven HCC in patients without cirrhosis.
Method: A retrospective review of CT and MRI imaging findings, age and sex, was performed in 10 patients with path-proven HCC.
Results: 100% of patients were male, with a median age of 64.9 years. Seven patients were reported as suspicious of HCC based on the imaging appearance. In all cases, there were no history of liver disease and liver profiles were normal. Dyslipidemia, diabetes and obesity were the most frequent comorbidity, found in 40% of cases. Tumor size was larger compared with the cirrhosis-related HCC patients due to active surveillance. Arterial enhancement, wash out, and the presence of intralesional fat were the most identified imaging findings.
Conclusions: The presence of typical CT and MRI imaging features may rise the suspicion of HCC in patients with no underlying hepatocellular disease.
Keywords: Hepatocellular carcinoma. Non cirrhotic liver. Non-alcoholic fatty liver disease. Computed tomography. Magnetic resonance imaging.
